MT-1 (Melanotan 1) — 5mg
Melanotan 1 (Afamelanotide, MT-1) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). It is a linear peptide that acts as a non-selective melanocortin receptor agonist and has been the subject of dermatological and photoprotection research.
Specifications
- Sequence
- [Nle⁴, D-Phe⁷]-α-MSH analog (linear)
- Molecular Weight
- ~1,646 Da
- Quantity
- 5mg per vial
- Purity
- ≥98% (HPLC verified)
- Form
- Lyophilized powder
- Appearance
- White powder
- Storage
- -20°C recommended
Research Applications
MT-1 (afamelanotide) has been studied in melanocortin receptor biology, specifically MC1R agonist activity and downstream melanogenesis pathways. An implantable formulation (Scenesse®) received FDA approval in 2019 for the specific indication of erythropoietic protoporphyria (EPP), a rare genetic disorder. Research-grade lyophilized MT-1 is used in preclinical receptor binding studies, melanocyte biology research, and photoprotection investigations.
Key Published Research
- Langendonk et al., NEJM 2015 — Afamelanotide Phase 3 EPP trial
- Fabrikant et al., Expert Opinion on Pharmacotherapy 2013 — Melanocortin receptor research
Storage & Handling
Store lyophilized powder at -20°C. Protect from light. Once reconstituted, store at 2-8°C and use within 28 days.